HMS Penelope was a fifth-rate frigate of the Royal Navy, launched in 1798 and wrecked in 1815.
Under Sir Henry Blackwood, she took part in the battle of 30 March 1800 against the Guillaume Tell, off the coast of Valetta, Malta. The British squadron off Malta comprised the 80-gun Foudroyant, the elderly 74-gun Alexander and 64-gun Lion and the 36-gun Penelope. The squadron wa supported by the big Minorca.
The Guillaume Tell had put to sea in the evening of 30 March under the command of French Admiral Denis Decrès. She was sighted by crew aboard Penelope slightly before midnight, heading northeast. Blackwood ordered an immediate pursuit and sent word via Minorca to the rest of the fleet. A first broadside was fired at about 1am, but Guillaume Tell continued on her course without returning fire. By dawn,Penelope had again drawn within range of the larger French vessel, and Blackwood ordered a continued raking fire which brought down Guillaume Tell's main and mizzen topmasts.
Penelope's sister ships Lion and Foudroyant hove into view shortly afterward, and engaged Guillaume Tell at close range, disabling her rigging and causing damage to her hull. Both British ships were badly damaged by the time Guillaume Tell struck her colours, and it was Penelope that took the French ship in tow and led her as a prize to Syracuse. Penelope lost two killed and two wounded in the battle. Blackwood was later commended for his gallantry and perseverance in initially engaging the French ship despite her larger size and firepower.
Northumberland, Alexander, Penelope, Bonne Citoyenne, and the brig Vincejo shared in the proceeds of the French polacca Vengeance, captured entering Valletta, Malta on 6 April.
Because Penelope served in the navy's Egyptian campaign (2 March to 8 September 1801), her officers and crew qualified for the clasp "Egypt" to the Naval General Service Medal that the Admiralty authorised in 1850 for all surviving claimants.
From 1803, Penelope served in the English Channel under William Robert Broughton.
Penelope shared with Moselle and Boadicea in the proceeds of the Jonge Obyna, Smidt, master, on 13 June 1805